<i>In vitro</i>and<i>ex vivo</i>nano-enabled immunomodulation by the protein corona
Francesca Giulimondi, Luca Digiacomo, Elisabetta Vulpis, Luisa Loconte, Gianmarco Ferri, Francesco Cardarelli, Daniela Pozzi, Alessandra Zingoni, Giulio Caracciolo
Abstract
. In human monocytes, GSN modulates the production of tumor necrosis factor alpha (TNF-α) in an inverse dose-dependent manner. Overall, our results suggest that artificial coronas can be exploited to finely tune the immune response, opening new approaches for the prevention and treatment of diseases.
Topics & Concepts
Ex vivoNano-In vitroIn vivoNanotechnologyMaterials scienceBiophysicsCell biologyChemistryBiologyBiochemistryComposite materialBiotechnologyNanoparticle-Based Drug DeliveryElectrospun Nanofibers in Biomedical ApplicationsRNA Interference and Gene Delivery