Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis
Shanshan He, Gang Li, Andreas G. Schätzlein, Peter A. Humphrey, Robert M. Weiss, Ijeoma F. Uchegbu, Darryl T. Martin
Topics & Concepts
Ku70Cancer researchCisplatinApoptosisBladder cancerViability assayCancer cellDNA repairGene knockdownCancerBiologyChemistryCell biologyMolecular biologyChemotherapyDNABiochemistryGeneticsBladder and Urothelial Cancer TreatmentsDNA Repair MechanismsUbiquitin and proteasome pathways