Silencing LINC00482 inhibits tumor-associated inflammation and angiogenesis through down-regulation of MMP-15 via FOXA1 in bladder cancer
Yizhuo Wang, Liping Zhang, Na Wei, Yue Sun, Weiyun Pan, Yan Chen
Abstract
, which was found to be reversed by the overexpression of MMP15. The present study demonstrated that LINC00482 induced the expression of MMP15 by interacting with FOXA1, thereby contributing to the inflammation and angiogenesis in bladder cancer.
Topics & Concepts
AngiogenesisGene silencingMatrix metalloproteinaseFOXA1InflammationCancer researchCancerBladder cancerMedicineChemistryImmunologyInternal medicineBiochemistryGeneBreast cancerCancer-related molecular mechanisms researchCircular RNAs in diseasesMicroRNA in disease regulation