Studies of the stability, nucleophilic substitution reactions, DNA/BSA interactions, cytotoxic activity, DFT and molecular docking of some tetra- and penta-coordinated gold(<scp>iii</scp>) complexes
Snežana Radisavljević, Ana Kesić, Dušan Ćoćić, Ralph Puchta, Laura Senft, Milena Milutinović, Nevena Milivojević, Biljana Petrović
Abstract
The stability in water and at pH = 7.2, substitution reactions with Tu, 5’-GMP, GSH and<sc>l</sc>-Met, DNA/BSA interactions, cytotoxicity, DFT and molecular docking of gold(<sc>iii</sc>) complexes with phenanthroline derivatives as inert ligands were studied.
Topics & Concepts
ChemistryNucleophilic substitutionCytotoxicityDocking (animal)TetraNucleophileSubstitution reactionPhenanthrolineStereochemistryCombinatorial chemistryInertDNAAdductMedicinal chemistryIn vitroOrganic chemistryBiochemistryCatalysisMedicineNursingMetal complexes synthesis and propertiesInorganic and Organometallic ChemistryFerrocene Chemistry and Applications