Epstein-Barr Virus Synergizes with BRD7 to Conquer c-Myc-Mediated Viral Latency Maintenance via Chromatin Remodeling
Shen Li, Yang Li, Yanling Li, Wenxing Yue, Shuyu Xin, Jing Li, Sijing Long, Wentao Zhang, Pengfei Cao, Jianhong Lu
Abstract
, and disruption of BRD7 decreased c-Myc expression to reactivate the lytic cycle. We also demonstrated that EBV-encoded EBNA1 bound to and regulated BRD7. Therefore, we reveal a novel mechanism by which EBV can regulate its infection state by coordinating with host BRD7 to target c-Myc. Our findings will help future therapeutic intervention strategies for EBV infection and pathogenesis.
Topics & Concepts
BZLF1Lytic cycleBiologyVirus latencyChromatinChromatin immunoprecipitationChromatin remodelingEnhancerVirologyGeneticsViral replicationVirusGeneTranscription factorGene expressionPromoterHerpesviridaeViral diseaseViral-associated cancers and disordersChromatin Remodeling and CancerLymphoma Diagnosis and Treatment