Activation of P2Y1R impedes intestinal mucosa repair during colitis
Qiuchan Huan, Peng Jiao, Yaoyao Chang, Qiansheng Zhang, Tianhang Xing, Danling Jiang, Wenke Chen, Xiangchun Shen, Zhaoxiang Bian, Haitao Xiao
Abstract
mice. Mechanistic investigation revealed that P2Y1R inhibition facilitated epithelial AMP-activated protein kinase (AMPK) phosphorylation and gut microbiota homeostasis reconstruction. Taken together, these findings highlight that P2Y1R activation plays an important role in impeding intestinal mucosa repair during colitis, and that P2Y1R is an attractive target for the therapy of IBD.
Topics & Concepts
ColitisIntestinal mucosaInflammatory bowel diseaseUlcerative colitisInflammationImmunologyWound healingIntestinal epitheliumBiologyIntestinal permeabilityMedicineEpitheliumPathologyDiseaseInternal medicineGut microbiota and healthAdenosine and Purinergic SignalingHelicobacter pylori-related gastroenterology studies