Sensitive determination of vincristine in plasma of children with leukaemia using vortex-assisted dispersive liquid–liquid microextraction based on hydrophobic deep eutectic solvent
Mohammad Reza Golpayegani, Reza Akramipour, Simin Gheini, Mazyar Vakili Amini, Farshad Fattahi, Ali Mohebbi, Nazir Fattahi
Abstract
and acceptable extraction efficiency (EE) of 88.4%. In the final stage of the study, this proposed technique was successfully applied to determine vincristine in real plasma, and the obtained results demonstrated the ability of the synthesized DES to extract drugs from biological fluids.
Topics & Concepts
Eutectic systemDeep eutectic solventSolventLiquid liquidPlasmaChromatographyVortexChemistryMaterials scienceAnalytical Chemistry (journal)Organic chemistryPhysicsThermodynamicsAlloyQuantum mechanicsAnalytical chemistry methods developmentAnalytical Chemistry and ChromatographyAnalytical Methods in Pharmaceuticals