Detection of GDF11 by using a Ti<sub>3</sub>C<sub>2</sub>-MXene-based fiber SPR biosensor
Chunlan Liu, Rui Wang, Yabin Shao, Chen Chen, Ping Wu, Yong Wei, Yachen Gao
Abstract
In the research of resistant aging, the concentration of Growth differentiation factor-11(GDF11) is an indispensable parameter. So the accurate detection of GDF11 is very important in life science and medical cosmetology. Hereby, we proposed and demonstrated a simple method to detect low concentration GDF11 by using fiber surface plasmon resonance (SPR) sensor decorated with two-dimension (2D) material Ti 3 C 2 -MXene and gold nanosphere. The sensitivity of the fiber SPR sensor was increased to be 4804.64nm/RIU. After functionalized with GDF11 antibody, the fiber SPR sensor could specifically recognize GDF11, and the limit of detection (LOD) can reach 0.577pg/L which is 100 times lower than that of single-molecule ELISA method.