FeCl<sub>3</sub>‐Catalyzed C(<i>sp</i><sup>3</sup>)−H Heteroarylation Enabled by Photoinduced Ligand‐to‐Metal Charge Transfer
Pengcheng Li, Jia‐Lin Tu, Han Gao, Chengcheng Shi, Yining Zhu, Lin Guo, Chao Yang, Wujiong Xia
Abstract
Abstract Herein, we report a strategy for pyrimidination of inert alkanes via synergistic visible light‐driven redox reaction and FeCl 3 catalysis. This transformation involves C−H activation by a chlorine radical generated during the iron‐promoted ligand‐to‐metal charge transfer process, triggering subsequent C−H pyrimidination. The substrates and catalysts are inexpensive and readily available, while the reaction conditions and procedures are simple without the need for external oxidants. This work provides a practical approach for synthesizing pyrimidine derivatives with high structural diversity.
Topics & Concepts
ChemistryCatalysisLigand (biochemistry)MetalRedoxPhotochemistryPyrimidineInertCombinatorial chemistryChlorineStereochemistryInorganic chemistryOrganic chemistryReceptorBiochemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques