Mib2 Deficiency Inhibits Microglial Activation and Alleviates Ischemia-Induced Brain Injury
Xiaoheng Li, Yajin Liao, Yuan Dong, Shuoshuo Li, Fengchao Wang, Rong Wu, Zengqiang Yuan, Jinbo Cheng
Abstract
significantly alleviates ischemia-induced neuroinflammation and brain injury. Taken together, our results reveal a critical role of Mib2 in microglial activation and ischemia-induced brain injury, thus providing a potential target for the treatment of stroke.
Topics & Concepts
NeuroinflammationMicrogliaIschemiaUbiquitin ligaseMedicineLipopolysaccharideImmune systemNeuroscienceKnockout mouseCentral nervous systemSignal transductionInflammationPharmacologyUbiquitinImmunologyCell biologyChemistryBiologyReceptorInternal medicineBiochemistryGeneNeuroinflammation and Neurodegeneration MechanismsNF-κB Signaling PathwaysAdenosine and Purinergic Signaling