Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
Yueying Zhou, Xiaonan Xin, Lichao Wang, Binsheng Wang, Li Chen, Ousheng Liu, David W. Rowe, Ming Xu
Abstract
The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations.
Topics & Concepts
Mesenchymal stem cellBone marrowMedicineStem cellBiologyPathologyCell biologyMesenchymal stem cell researchBone Metabolism and DiseasesTelomeres, Telomerase, and Senescence