A shared genetic contribution to breast cancer and schizophrenia
Donghao Lu, Jie Song, Yi Lu, Katja Fall, Xu Chen, Fang Fang, Mikael Landén, Christina M. Hultman, Kamila Czene, Patrick F. Sullivan, Rulla M. Tamimi, Unnur Valdimarsdóttir
Abstract
An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic and genetic positive associations of schizophrenia with breast cancer and vice versa, based on a Swedish population-based cohort and GWAS data from international consortia. We observe a genetic correlation of 0.14 (95% CI 0.09-0.19) and identify a shared locus at 19p13 (GATAD2A) associated with risks of breast cancer and schizophrenia. The epidemiological bidirectional association between breast cancer and schizophrenia may partly be explained by the genetic overlap between the two phenotypes and, hence, shared biological mechanisms.