Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets
Tiansu Wang, Allison R. Pine, Andriana G. Kotini, Han Yuan, Lee Zamparo, Daniel T. Starczynowski, Christina S. Leslie, Eirini P. Papapetrou
Topics & Concepts
BiologyCRISPRGenome editingMyeloid leukemiaDiseaseMyeloidInduced pluripotent stem cellComputational biologyGeneLeukemiaMyeloid cellsGeneticsCancer researchEmbryonic stem cellPathologyMedicineAcute Myeloid Leukemia ResearchCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniques