Downregulation of enhancer RNA EMX2OS is associated with poor prognosis in kidney renal clear cell carcinoma
Huiming Jiang, Haibin Chen, Pei Wan, Shengda Song, Nanhui Chen
Abstract
as its target. EMX2OS downregulation was significantly associated with higher histological grade, advanced stage, and poorer prognosis. The results were validated in pan-cancer data from The Cancer Genome Atlas and RT-qPCR analysis of 12 pairs of KIRC and normal real-world samples. Functional enrichment analysis indicated that several metabolism-associated signaling pathways were enriched. This study demonstrated that EMX2OS is a key metabolism-associated enhancer RNA in KIRC with a favorable impact on survival and may be a novel therapeutic target in KIRC.
Topics & Concepts
Downregulation and upregulationRenal cell carcinomaEnhancerCancer researchKidneyRNACarcinomaMedicineBiologyOncologyInternal medicineGene expressionGeneGeneticsRNA modifications and cancerCircular RNAs in diseasesRenal and related cancers