Fe-Curcumin Nanozyme-Mediated Reactive Oxygen Species Scavenging and Anti-Inflammation for Acute Lung Injury
Renyikun Yuan, Yuqing Li, Shan Han, Xinxin Chen, Jingqi Chen, Jia He, Hongwei Gao, Yang Yang, Shilin Yang, Yu Yang
Abstract
T cells in mice, which could help suppress the inflammation cytokine storm caused by ALI. Overall, this work has developed the strategy of using Fe-Cur NPs as nanozymes to scavenge intracellular ROS and as an anti-inflammation nanodrugs to synergistically cure ALI, which may serve as a promising therapeutic agent in the clinical treatment of this deadly disease. Fe-Cur NP nanozymes were designed to attenuate ALI by clearing intracellular ROS and alleviating inflammation synergistically. Relevant cytokines, inflammasomes, and signaling pathways were studied.
Topics & Concepts
CurcuminReactive oxygen speciesInflammationScavengingChemistryLungPharmacologyMedicineImmunologyBiochemistryAntioxidantInternal medicineAdvanced Nanomaterials in CatalysisAdvanced Glycation End Products researchMosquito-borne diseases and control