Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and <i>mTOR</i> expression, as a novel component, in a rat model of Polycystic ovary syndrome.
Faeze Fazel Torshizi, Mohammad Chamani, Hamid Reza Khodaei, Ali Asghar Sadeghi, Seyed Hossein Hejazi, Reza Majidzadeh Heravi
Abstract
OBJECTIVES: gene expression, and pathogenesis of PCOS in a rat model induced-PCOS. MATERIALS AND METHODS: Experimental treatments were performed on control and treated groups, consisting of healthy controls (Control, water, and standard feed intake and daily injection of sesame oil alone), Polycystic control (PCO, injection of 4 mg/kg estradiol valerate (EV) for four weeks). Treated groups (PCO-ZM 25, PCO-ZM 75, and PCO-ZM 175) after 4 weeks of receiving EV, were daily given three levels of 25, 75, and 175 mg zinc methionine/kg BW for 15 days, respectively. RESULTS: <0.05). CONCLUSION: expression, restored the hormonal profile, and decreased the number of cysts in the ovaries.