E3 ligase FBXW7 restricts M2-like tumor-associated macrophage polarization by targeting c-Myc
Lijia Zhong, Yuanyuan Zhang, Mengyao Li, Yinjing Song, Danhui Liu, Xin Yang, Dehua Yang, Hao Qu, Lihua Lai, Qingqing Wang, Zhimin Chen
Abstract
, FBXW7-knockout macrophages displayed increased M2 macrophage polarization and enhanced ability of supporting cancer cells growth. In mechanism, we confirmed that FBXW7 inhibited M2-like TAM polarization by mediating c-Myc degradation via the ubiquitin-proteasome system. These findings highlight the role of FBXW7 in M2-like TAM polarization and provide new insights into the potential targets for cancer immunotherapies.
Topics & Concepts
Ubiquitin ligaseMacrophage polarizationCell biologyDNA ligaseCancer researchChemistryMacrophageBiologyUbiquitinBiochemistryDNAGeneIn vitroImmune cells in cancerProtein Degradation and InhibitorsPhagocytosis and Immune Regulation