Engineered elastin-like polypeptide-based hydrogel delivering chemotherapeutics and PD-L1 antibodies for potentiated cancer immunotherapy
Jinguang Chen, Meiying Cui, Lianping He, Yeteng Mu, Nannan Hu, Xingang Guan
Abstract
T cells and 60% Tregs depletion compared with PBS group, eliciting a robust antitumor immune response for immunotherapy in melanoma mouse models. This research highlights the promising potential of ELP-based hydrogels in delivering ICIs and chemotherapeutic agents for potentiated cancer immunotherapy.
Topics & Concepts
ElastinCancer immunotherapyImmunotherapyAntibodyCancer researchCancerSelf-healing hydrogelsMaterials scienceMedicinePharmacologyImmunologyInternal medicinePolymer chemistryPathologyConnective tissue disorders researchNanoplatforms for cancer theranosticsHydrogels: synthesis, properties, applications