Lignans and Terpenoids from the Leaves of <i>Schisandra chinensis</i>
Guozhen Liu, Yan Liu, Yanping Sun, Xiao‐Mao Li, Zhen‐Peng Xu, Peng Jiang, Xiaohui Rong, Bing‐You Yang, Haixue Kuang
Abstract
Abstract Fifteen constituents, including one new lignan (schisandroside E) and one new terpenoid (schisandenoid A) as well as nine known lignans and four known terpenoids, were isolated from Schisandra chinensis leaves. The structures of schisandroside E and schisandenoid A were established by entirely meticulous spectroscopic analysis (NMR, MS, CD, IR and UV). All compounds were tested for cytotoxicity against MGC‐803, Caco‐2 and Ishikawa cell lines. Some compounds showed strong cytotoxicity against these three cancer cell lines with IC 50 <1 μ m .
Topics & Concepts
LignanTerpenoidSchisandra chinensisChemistryCytotoxicitySchisandraCancer cell linesTwo-dimensional nuclear magnetic resonance spectroscopyStereochemistryTraditional medicineIn vitroCancer cellBiochemistryCancerBiologyTraditional Chinese medicineAlternative medicineGeneticsMedicinePathologyPlant-derived Lignans Synthesis and BioactivityPhytochemistry and Biological ActivitiesNatural Compound Pharmacology Studies