Multidimensional biocircuitry of exercise adaptation: integrating in vivo and ex vivo phenomics with miRNA mapping
Jeremy S. McAdam, Michael P. Craig, Zachary Graham, Brandon K. Peoples, S. Craig Tuggle, Regina Seay, Kaleen M. Lavin, Amber B. Gargus, Samia M. O’Bryan, Sufen Yang, Devin Drummer, Christian Kelley, Kalyani Peri, Margaret B. Bell, Inmaculada Aban, Gary Cutter, Arash Mahyari, Yuan Wen, Jin Zhang, Akshay Hira, Timothy J. Broderick, Madhavi Kadakia, Marcas M. Bamman
Abstract
We examined in vivo and ex vivo adaptations to traditional moderate-intensity endurance and resistance training (TRAD) versus high-intensity tactical training (HITT; explosive whole-body interval training and high-intensity resistance training). TRAD and HITT improved physiological performance and body composition, and induced ex vivo muscle adaptations, with remarkable interindividual response heterogeneity (IRH) in improvements. We leveraged multidimensional modeling to identify interindividual response heterogeneity biocircuitry that integrates deep phenotyping and miR transcriptomics (serum exosomes and skeletal muscle).