Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer
Yanan Liu, Canwei Wang, Jifa Li, Jiandong Zhu, Chengguang Zhao, Huanhai Xu
Abstract
Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding. Excessive expression of the receptor and its ligand, especially FGF19, occurs in many types of cancer. Abnormal FGFR4 production explains these cancer formations, and therefore, this receptor has emerged as a potential target for inhibiting cancer development. This review discusses the diverse mechanisms of oncogenic activation of FGFR4 and highlights some currently available inhibitors targeting FGFR4.
Topics & Concepts
Fibroblast growth factor receptor 4Receptor tyrosine kinaseFibroblast growth factor receptorCancer researchFibroblast growth factor receptor 2Tyrosine kinaseFGF19Fibroblast growth factorCancerGrowth factor receptorReceptorBiologyCell biologySignal transductionGeneticsFibroblast Growth Factor ResearchKruppel-like factors researchEosinophilic Disorders and Syndromes