Comments on "An insertion unique to SARS-CoV-2 exhibits super antigenic character strengthened by recent mutations" by Cheng MH et al. 2020
Francesco Chiappelli
Abstract
In brief, this is an experimental study with major clinical relevance. The reported findings yield a new understanding of the immunopathology leading to severe manifestations of CoViD-19, in adults and children, which is of critical importance for effective management and treatment of the disease, as well as for preventive measures against future waves of SARS-CoV-2 infection. It appears possible and even probable that the promising findings proffered in this study may point to novel immuno-modulatory therapeutic options for patients with CoViD-19 or MIS-C.
Topics & Concepts
Character (mathematics)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)VirologyComputer scienceBiologyGeneticsComputational biologyMedicineMathematicsPathologyGeometryDiseaseInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchImmunodeficiency and Autoimmune DisordersImmunotherapy and Immune Responses