Pharmacopuncture of <i>Bauhinia variegata</i> Nanoemulsion Formulation against Diabetic Peripheral Neuropathic Pain
Pushpraj S Gupta, Sunil Kumar Singh, Abhishek Tripathi
Abstract
OBJECTIVES: loaded nanoemulsion(formulation and determine the efficacy of herbal drug formulation against diabetic peripheral neuropathic pain through acupuncture technique. METHODS: extract ( treated group (100 mg/kg/day, p.o) and Group IV was BVN treated groups (100 mg/kg/day, p.o) acute and chronically. RESULTS: loaded nanoemulsion was nanosized (124 nm), spherical, uniform and stable over the period of 180 days with no change in physiochemical properties. The bl ood glucose and body weight of animals was normalizing after four weeks of treatment that was significant with BVN in comparison to diabetic control group. The chronic administration of BVN significantly (P<0.001) decreased hind paw withdrawal latency an d attenuated mechanical allodynia as compared with diabetic rats. CONCLUSION: Thus, BVN may be an effective drug formulation against diabetic peripheral neuropathic pain.