Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications
Stefano Morotti, Caroline Liu, Bence Hegyi, Haibo Ni, Alex Fogli Iseppe, Lianguo Wang, Marco Pritoni, Crystal M. Ripplinger, Donald M. Bers, Andrew G. Edwards, Eleonora Grandi
Abstract
transient in mouse, rabbit, and human. We then tested our translators against experimental data describing the response to stimuli, such as ion channel block, change in beating rate, and β-adrenergic challenge. We demonstrate that this approach is well suited to predicting the effects of perturbations across different species or experimental conditions and suggest its integration into mechanistic studies and drug development pipelines.
Topics & Concepts
Cardiac myocyteElectrophysiologyMyocyteCardiac electrophysiologyComputer scienceNeuroscienceCardiovascular physiologyComputational biologyBiologyMedicineInternal medicineCell biologyCardiac electrophysiology and arrhythmiasProtein Structure and DynamicsIon channel regulation and function