Hyperactive Innate Immunity Causes Degeneration of Dopamine Neurons upon Altering Activity of Cdk5
Arvind Kumar Shukla, Joshua Spurrier, Irina Kuzina, Edward Giniger
Abstract
(Cell Reports 26, 131–144.e1–e4; January 2, 2019) In the originally published version of this article, Tables S1 and S4 were omitted from the supplemental information PDF. The corrected version of the supplemental information PDF appears here, including the previously omitted Tables S1 and S4. The authors regret this error. Download .pdf (6.05 MB) Help with pdf files Hyperactive Innate Immunity Causes Degeneration of Dopamine Neurons upon Altering Activity of Cdk5Shukla et al.Cell ReportsJanuary 02, 2019In BriefHow can one disentangle the many pathologies of neurodegeneration from one another and from normal aging? Shukla et al. show that a mutation in Drosophila kills neurons by impairing autophagy, which in turn stimulates neurotoxic levels of innate immunity, and this acts synergistically with a parallel pathway that accelerates aging. Full-Text PDF Open Access