Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility
Lukas Schmidheini, Nicolas Mathis, Kim Fabiano Marquart, Tanja Rothgangl, Lucas Kissling, Desirée Böck, Christelle Chanez, Jingrui Priscilla Wang, Martin Jínek, Gerald Schwank
Topics & Concepts
CRISPRNucleaseBiologyGenome editingCas9Computational biologyGeneticsGenome engineeringDirected evolutionDirected Molecular EvolutionGeneMutantCRISPR and Genetic EngineeringInnovation and Socioeconomic DevelopmentAnimal Genetics and Reproduction