The synthesis of anticancer sulfonated indolo[2,1-<i>a</i>]isoquinoline and benzimidazo[2,1-<i>a</i>]isoquinolin-6(5<i>H</i>)-ones derivatives <i>via</i> a free radical cascade pathway
Youlu Pan, Xiaomeng Gong, Rongrong Hao, Shenxin Zeng, Zhengrong Shen, Wenhai Huang
Abstract
)-ones in moderate to good yields. In particular, some compounds exhibit bioactivity against cancer cell lines. This protocol shows advantages of low-cost, base-free, simple operation, and broad functional group tolerance.
Topics & Concepts
IsoquinolineChemistryCombinatorial chemistryFunctional groupFree baseStereochemistryOrganic chemistryPolymerSalt (chemistry)Sulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions