Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
Benjamin J. Andreone, Laralynne Przybyla, Ceyda Llapashtica, Anil Rana, Sonnet S. Davis, Bettina van Lengerich, Karin Lin, Ju Shi, Mei Yuan, Giuseppe Astarita, Gilbert Di Paolo, Thomas Sandmann, Kathryn M. Monroe, Joseph W. Lewcock
Topics & Concepts
TREM2MicrogliaBiologyNeuroscienceReceptorPhenotypeCell biologyInflammationImmunologyGeneGeneticsNeuroinflammation and Neurodegeneration MechanismsInflammation biomarkers and pathwaysNeurological Disease Mechanisms and Treatments