Site-specific deacylation by ABHD17a controls BK channel splice variant activity
Heather McClafferty, Hamish Runciman, Michael J. Shipston
Abstract
-acylated domains in the same polytopic transmembrane protein can be regulated by different acyl protein thioesterases revealing mechanisms for generating both specificity and diversity for these important enzymes to control the properties and functions of ion channels.
Topics & Concepts
Ion channelTransmembrane proteinTransmembrane domainChemistryBiochemistryBiophysicsInward-rectifier potassium ion channelBiologyAmino acidReceptorIon channel regulation and functionNicotinic Acetylcholine Receptors StudyAdenosine and Purinergic Signaling