Live-bearing cockroach genome reveals convergent evolutionary mechanisms linked to viviparity in insects and beyond
Bertrand Fouks, Mark C. Harrison, Alina A. Mikhailova, Elisabeth Marchal, Sinéad English, Madeleine Carruthers, Emily C. Jennings, Ezemuoka L. Chiamaka, Ronja Frigard, Martin Pippel, Geoffrey M. Attardo, Joshua B. Benoit, Erich Bornberg‐Bauer, Stephen S. Tobe
Abstract
Live birth (viviparity) has arisen repeatedly and independently among animals. We sequenced the genome and transcriptome of the viviparous Pacific beetle-mimic cockroach and performed comparative analyses with two other viviparous insect lineages, tsetse flies and aphids, to unravel the basis underlying the transition to viviparity in insects. We identified pathways undergoing adaptive evolution for insects, involved in urogenital remodeling, tracheal system, heart development, and nutrient metabolism. Transcriptomic analysis of cockroach and tsetse flies revealed that uterine remodeling and nutrient production are increased and the immune response is altered during pregnancy, facilitating structural and physiological changes to accommodate and nourish the progeny. These patterns of convergent evolution of viviparity among insects, together with similar adaptive mechanisms identified among vertebrates, highlight that the transition to viviparity requires changes in urogenital remodeling, enhanced tracheal and heart development (corresponding to angiogenesis in vertebrates), altered nutrient metabolism, and shifted immunity in animal systems.