Novel AP2238-clorgiline hybrids as multi-target agents for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation
Guohui Zhong, Jie Guo, Chengyun Pang, Di Su, Chunli Tang, Lin Jing, Fengling Zhang, Pingnian He, Yaqian Yan, Zongji Chen, Jing Liu, Neng Jiang
Topics & Concepts
IC50ChemistryMonoamine oxidaseCholinesteraseAchéAcetylcholinesterasePharmacologyMonoamine oxidase BToxicityInhibitory postsynaptic potentialPotencyMonoamine neurotransmitterIn vitroEnzymeBiochemistryInternal medicineMedicineReceptorSerotoninOrganic chemistryCholinesterase and Neurodegenerative DiseasesMedicinal Plants and NeuroprotectionAlzheimer's disease research and treatments