Direct Chiral <sup>19</sup>F NMR Analysis of Fluorine-Containing Analytes and Its Application to Simultaneous Chiral Analysis
Sumin Jang, Hyunwoo Kim
Abstract
We have demonstrated the efficient chiral analysis of fluorine-containing compounds by 19F NMR spectroscopy. The highly sensitive fluorine nucleus allowed chiral analysis of complex mixtures and even asymmetric reaction mixtures of multisubstrates. A single 19F NMR experiment was sufficient to determine the enantiomeric excesses and yields of the five products simultaneously.
Topics & Concepts
ChemistryFluorine-19 NMRFluorineEnantiomerNuclear magnetic resonance spectroscopyChiral derivatizing agentOrganic chemistryComputational chemistryChiral column chromatographyMolecular spectroscopy and chiralityAnalytical Chemistry and ChromatographyFluorine in Organic Chemistry