Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non‐Responders to Immunotherapy (Adv. Sci. 35/2025)
Xiangxiang Xu, Lu Diao, Jin Wang, Ao Zhu, Xianlan Chen, Yan Zheng, Yuhan Liu, Kang Hu, Jiashan Zhu, Cheng Ding, Chang Li, Yunzhi Pan, Jun Zhao, Mi Liu
Abstract
Cancer Vaccines In the Research Artikel (DOI: 2416756), Jun Zhao, Mi Liu, and co-workers investigate adjuvants, collection, lysis, purification, oxidation, loading sites, sizes etc. to maximize the efficacy of cancer vaccines. The optimized cancer nanovaccines loading whole tumor antigens can cure most tumor-bearing mice in multiple mouse cancer models. The landscape of immune cells in the blood, splenocytes, and draining lymph nodes of vaccine-treated mice are studied.
Topics & Concepts
ImmunotherapyImmune systemMedicineCancerCancer immunotherapyImmunologyOral immunotherapyCancer researchCancer treatmentImmune escapeAntigenAntibodyCancer cellNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryAdvanced Nanomaterials in Catalysis