CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease
Maximilian Frosch, Lukas Amann, Marco Prinz
Abstract
In an alpha-synuclein (α-syn) model of Parkinson’s disease (PD), Schonhoff and colleagues have shown that central nervous system (CNS)-associated macrophages (CAMs), but not microglia, potentially orchestrate CD4+ T cell recruitment and mediate an α-syn-induced inflammatory makeup.
Topics & Concepts
MicrogliaParkinson's diseaseCentral nervous systemDiseaseNeuroscienceInflammationAlpha-synucleinInflammatory responseNeuroinflammationImmunologyMacrophageBiologyMedicinePathologyGeneticsIn vitroNeuroinflammation and Neurodegeneration MechanismsNerve injury and regenerationNeurogenesis and neuroplasticity mechanisms