Sustainable electrochemical dearomatization for the synthesis of diverse 2, 3-functionalized indolines
Jun Chen, Rong Zhang, Caiyan Ma, Peng Zhang, Yonghong Zhang, Bin Wang, Fei Xue, Weiwei Jin, Yu Xia, Chenjiang Liu
Abstract
Herein, we achieved a green and efficient dearomatization for the synthesis of 2,3-functionalized polycyclic indolines in an electrochemical way. This avoiding of external oxidants and metals approach allowed various nucleophilic sources (Nu = anilines, TMSN3 and ROH) to perform the products, representing an environmentally benign means. Additionally, the continuous flow electrosynthesis and synthetic transformations also reveal the strong practicality of electrochemistry in organic synthesis.
Topics & Concepts
ElectrosynthesisElectrochemistryOrganic synthesisChemistryNucleophileCombinatorial chemistryOrganic chemistryCatalysisElectrodePhysical chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques