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Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents

Liyu Zhao, Yin Sun, Wenbo Yin, Linfeng Tian, Nannan Sun, Yang Zheng, Chu Zhang, Shizhen Zhao, Xin Su, Dongmei Zhao, Maosheng Cheng

2021European Journal of Medicinal Chemistry11 citationsDOIOpen Access PDF

Topics & Concepts

Cryptococcus neoformansChemistryAspergillus fumigatusCandida albicansAntifungalCYP3A4StereochemistryBroad spectrumPharmacokineticsMinimum inhibitory concentrationIn vitroBiological activityChemical synthesisPharmacologyMetabolismCytochrome P450BiochemistryCombinatorial chemistryMicrobiologyMedicineBiologySynthesis and Biological EvaluationSynthesis and biological activityCancer therapeutics and mechanisms
Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents | Litcius