Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation
Hongxu Xian, Yuan Liu, A. Nilsson, Raphaella Gatchalian, Timothy R. Crother, Warren G. Tourtellotte, Yi Zhang, Germán Rodrigo Alemán-Muench, Gavin Lewis, Weixuan Chen, Sarah Kang, Melissa Luevanos, Dorit Trudler, Stuart A. Lipton, Pejman Soroosh, John R. Teijaro, Juan Carlos de la Torre, Moshe Arditi, Michael Karin, Elsa Sánchez‐López
Topics & Concepts
InflammasomeARDSMetforminAMPKBiologyAMP-activated protein kinaseInflammationLipopolysaccharideProtein kinase APharmacologyCell biologyImmunologyKinaseMedicineLungInternal medicineEndocrinologyDiabetes mellitusInflammasome and immune disordersPhagocytosis and Immune RegulationImmune cells in cancer