Stearoyl-CoA desaturase 1: A potential target for non-alcoholic fatty liver disease?-perspective on emerging experimental evidence
Shanmugam M. Jeyakumar, Ayyalasomayajula Vajreswari
Abstract
gene knockout and diet-induced rodent models have demonstrated that SCD1 plays a key role in the development of NAFLD, by modulating hepatic lipogenesis and thus triglyceride accumulation in the liver. Several pharmacological and dietary intervention studies have shown the benefits of inhibiting hepatic SCD1 in the pathogenesis of NAFLD. In this review, we give an overview of SCD1 in NAFLD, based on the current experimental evidence and the translational applicability of SCD1 inhibition in human NAFLD conditions, besides discussing the limitations and way-forward.
Topics & Concepts
LipogenesisFatty liverSteatohepatitisSteatosisMedicineInternal medicineEndocrinologyContext (archaeology)DiseaseLipid metabolismBiologyPaleontologyLiver Disease Diagnosis and TreatmentDiet, Metabolism, and DiseaseLipid metabolism and biosynthesis