The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation
Junchao Shi, Zi Li, Rongyi Xu, Jing Zhang, Qianyu Zhou, Rui Gao, Huijun Lu, Yungang Lan, Kui Zhao, Hongbin He, Feng Gao, Wenqi He
Abstract
and that the activated PERK/PKR-eIF2α axis inhibited PHEV replication through attenuating global protein translation and promoting SG formation. A better understanding of coronavirus-induced ERS and UPR activation may reveal the pathogenic mechanism of coronavirus and facilitate the development of new treatment strategies for these diseases.
Topics & Concepts
BiologyStress granuleProtein kinase RVirologyTranslation (biology)Viral replicationeIF2Cell biologyVirusGeneticsPhosphorylationProtein kinase AGeneMessenger RNAMitogen-activated protein kinase kinaseRNA regulation and diseaseEndoplasmic Reticulum Stress and DiseaseVirus-based gene therapy research