A ratiometric ESIPT probe based on 2-aza-Cope rearrangement for rapid and selective detection of formaldehyde in living cells
Tingting Quan, Zhenhao Liang, Huaiting Pang, Guanling Zeng, Tongsheng Chen
Abstract
2-aza-Cope rearrangement. The probe also displayed a fast response (<20 min) to both exogenous and endogenous FA in living cells. Besides, FormAFP was capable of monitoring FA released by folate degradation in living MCF7 cells. More importantly, FormAFP successfully detected fluctuations of endogenous FA levels in oxidative stress stimulation, demonstrating its potential as an ideal tool to explore FA biology.
Topics & Concepts
EndogenyFluorescenceChemistryStimulationKineticsBiophysicsFormaldehydeIntramolecular forceEpigeneticsDetection limitPhotochemistryBiochemistryBiologyStereochemistryGeneChromatographyEndocrinologyPhysicsQuantum mechanicsIndoor Air Quality and Microbial ExposurePhotodynamic Therapy Research StudiesAir Quality and Health Impacts