Lysosomal control of senescence and inflammation through cholesterol partitioning
Kyeonghwan Roh, Jeonghwan Noh, Yeonju Kim, Yeji Jang, Jae‐Jin Kim, Haebeen Choi, Yeonghyeon Lee, Moongi Ji, Donghyun Kang, Mi-Sung Kim, Man‐Jeong Paik, Jongkyeong Chung, Jin‐Hong Kim, Chanhee Kang
Topics & Concepts
SenescencemTORC1InflammationCholesterolLysosomeCell biologyDownregulation and upregulationBiologyABCA1Reverse cholesterol transportEndocrinologyBiochemistryImmunologySignal transductionTransporterEnzymeLipoproteinPI3K/AKT/mTOR pathwayGeneTelomeres, Telomerase, and SenescenceInflammasome and immune disordersAutophagy in Disease and Therapy