Features and roles of T helper 22 cells in immunological diseases and malignancies
Nikoo Hossein‐Khannazer, Zeineb Zian, Joaira Bakkach, Alí N. Kamali, Ramin Hosseinzadeh, Abubakar Umar Anka, Reza Yazdani, Gholamreza Azizi
Abstract
T cells that primarily mediate biological effects on the epithelial barrier through interleukin (IL)-22. Although, new studies showed that both Th22 and IL-22 are closely associated with the pathogenesis of inflammatory, autoimmune and allergic disease as well as malignancies. In this review, we aim to describe the development and characteristics of Th22 cells as well as their roles in the immunopathogenesis of immune-related disorders and cancer.
Topics & Concepts
ImmunologyBiologyT helper cellT cellImmune systemIL-33, ST2, and ILC PathwaysImmune Cell Function and InteractionT-cell and B-cell Immunology