Visible-Light Photoredox-Catalyzed Difunctionalization of Alkynes with Quinoxalin-2(1<i>H</i>)-Ones, P<sub>4</sub>S<sub>10</sub>, and Alcohols
Lianhui Song, Chao Ma, Jian Huang, Yufen Lv, Huilan Yue, Jinmao You, Wei Wei, Dong Yi
Abstract
Visible-light photoredox-catalyzed method has been developed for the synthesis of quinoxalin-2(1 H )-one-containing vinyl phosphorodithioates via direct difunctionalization of alkynes with quinoxalin-2(1 H )-ones, P 4 S 10 and alcohols. This four-component reaction could be carried out under metal-free and mild conditions, affording a number of quinoxalin-2(1 H )-one-containing vinyl phosphorodithioates in moderate to good yields with Z-isomers as the major products. Photocatalytic radical mechanism is proposed based on the results of radical trapping and fluorescence quenching experiments.
Topics & Concepts
CatalysisVisible spectrumChemistryPhotochemistryMedicinal chemistryPhysicsOrganic chemistryOptoelectronicsSynthesis and Biological EvaluationFluorine in Organic ChemistryCO2 Reduction Techniques and Catalysts