Organocatalytic asymmetric azidation of sulfoxonium ylides: mild synthesis of enantioenriched α-azido ketones bearing a labile tertiary stereocenter
Wengang Guo, Feng Jiang, Shijia Li, Jianwei Sun
Abstract
An organocatalytic asymmetric H–N 3 insertion of α-carbonyl sulfoxonium ylides has been developed, providing efficient access to α -azido ketones bearing labile tertiary stereocenters and complementing the metal carbene insertion chemistry.
Topics & Concepts
StereocenterCarbeneChemistryOrganocatalysisStereochemistryTertiary careEnantioselective synthesisCombinatorial chemistryOrganic chemistryCatalysisFamily medicineMedicineSynthesis and Catalytic ReactionsCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods