Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae)
Bosco Peron Leutcha, Jean Paul Dzoyem, Jean‐Bosco Jouda, Denis Kehdinga Sema, Virginie Flaure Tsague Tankeu, Gabin Thierry M. Bitchagno, Billy Toussie Tchegnitegni, Flaure Rosette Ehawa Essoung, Bruno Ndjakou Lenta, Siméon F. Kouam, Florence Delié, Alain Méli Lannang, Norbert Sewald
Abstract
Twenty-two compounds were isolated from the fruit of Albizia lebbeck including one unprecedented, rare amino acid-derived zwitterionic and one new flavone derivative. The isolation was performed on repeated column chromatography over silica gel and their structures were determined by 1D-, 2D-NMR and HR-ESI-MS spectra together with reported data in the literature. The chemophenetic significance is also discussed. Some isolated compounds were reported for the first time to be found in the species. Additionally, compound 2 showed antibacterial activity and compounds 1 and 2 revealed moderate cytotoxic activity against the Raw 264.7 cancer cell line with IC50 values of 37.19 µM and 29.36 µM, respectively. Furthermore, a proposed biosynthetic pathway of compound 1 is described.