Oligonucleotide-Functionalized Gold Nanoparticles for Synchronous Telomerase Inhibition, Radiosensitization, and Delivery of Theranostic Radionuclides
Bas M. Bavelaar, Lei Song, Mark R. Jackson, Sarah Able, Ole Tietz, Irini Skaripa-Koukelli, Philip A. Waghorn, Martin R. Gill, Robert Carlisle, Madalena Tarsounas, Katherine A. Vallis
Abstract
In-Match-AuNP-Tat therefore holds promise as a vector for delivery of radionuclides into cancer cells while simultaneously sensitizing them to the effects of the emitted radiation.
Topics & Concepts
OligonucleotideTelomeraseChemistryColloidal goldCancer cellCancer researchMolecular biologyBiophysicsNanoparticleCancerDNABiochemistryBiologyNanotechnologyMaterials scienceGeneGeneticsRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesTelomeres, Telomerase, and Senescence