Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies
Shiqi Chen, Zehong Huang, Yue Guo, Huilin Guo, Lijuan Jian, Jin Xiao, Xiangyang Yao, Hai Yu, Tong Cheng, Yali Zhang, Ming Guan, Richeng Mao, Jiming Zhang, Ningshao Xia, Quan Yuan
Abstract
SARS-CoV-2 inevitably evolves toward being more robust at multiplying. In the herd immunity era, mutations allowing SARS-CoV-2 to bypass the immunity acquired from vaccinations or infections may be essential in improving viral transmission fitness 1 , 2 , 3 , 4 , 5 . However, how evasion mutations drive the evolution remains to be elucidated.
Topics & Concepts
VirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)AntibodyEvasion (ethics)Spike (software development)Coronavirus disease 2019 (COVID-19)Spike Protein2019-20 coronavirus outbreakBiologyMedicineGeneticsOutbreakImmune systemDiseaseInfectious disease (medical specialty)PathologyEconomicsManagementSARS-CoV-2 and COVID-19 ResearchMonoclonal and Polyclonal Antibodies ResearchBacillus and Francisella bacterial research