mDIXON-Quant technique diagnostic accuracy for assessing bone mineral density in male adult population
Rui Tang, Guangyu Tang, Hua Ting, Yun Tu, Rui Ji, Jingqi Zhu
Abstract
Abstract Background To investigate the diagnostic efficacy of mDIXON-Quant technique for prediction of bone loss in male adults. Methods One hundred thirty-eight male adults were divided into normal, osteopenia, and osteoporosis groups based on DXA and QCT for the lumbar spine. Differences in mDIXON-Quant parameters [fat fraction (FF) and T2 * value] among three groups, as well as the correlation of mDIXON-Quant parameters and bone mineral density (BMD) were analyzed. The areas under the curves (AUCs) for mDIXON-Quant parameters for prediction of low bone mass were calculated. Results According to DXA standard, FF and T2 * value were significantly increased in osteoporosis group compared with normal group ( P = 0.012 and P < 0.001). According to QCT standard, FF was significantly increased in osteopenia and osteoporosis groups compared with normal group (both P < 0.001). T2 * values were significantly different among three groups (all P < 0.05). After correction for age and body mass index, FF was negatively correlated with areal BMD and volumetric BMD ( r = -0.205 and -0.604, respectively; both P < 0.05), and so was T2 * value ( r = -0.324 and -0.444, respectively; both P < 0.05). The AUCs for predicting low bone mass according to DXA and QCT standards were 0.642 and 0.898 for FF, 0.648 and 0.740 for T2 * value, and 0.677 and 0.920 for both combined, respectively. Conclusions FF combined with T2 * value has a better diagnostic efficacy than FF or T2 * value alone in prediction of low bone mass in male adults, which is expected to be a promising MRI method for the screening of bone quality. Trial registration ChiCTR1900024511 (Registered 13–07-2019).