Stereoselective Copper‐Catalyzed Direct Aldol Reaction of β, γ‐Unsaturated α‐Ketoesters with Coumaran‐3‐Ones
Kuiliang Li, Xiang Sun, Linge Li, Zhenggen Zha, Feng‐Lian Zhang, Zhiyong Wang
Abstract
An efficient direct aldol reaction between coumaran-3-ones and β, γ-unsaturated α-ketoesters by virtue of a chiral copper complex is developed. A series of coumaran-3-one derivatives containing chiral tertiary alcohol structures are obtained in excellent yields and stereoselectivities.
Topics & Concepts
Aldol reactionStereoselectivityCopperChemistryCatalysisAlcoholOrganic chemistryAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry MethodsOxidative Organic Chemistry Reactions