<i>In vitro</i> functional models for human liver diseases and drug screening: beyond animal testing
Alessia Paradiso, Marina Volpi, Chiara Rinoldi, Nehar Celikkin, Nicola Contessi Negrini, Muge Bilgen, Giorgio Dallera, Filippo Pierini, Marco Costantini, Wojciech Święszkowski, Silvia Farè
Abstract
models have been proposed as an alternative to pre-clinical animal models. These systems have been successfully employed for the investigation of the etiology and dynamics of liver diseases, for drug screening, and - more recently - to design patient-tailored therapies, resulting in potentially higher efficacy and reduced costs compared to other methods. Here, we review the most recent advances in this rapidly evolving field with particular attention to organoid cultures, liver-on-a-chip platforms, and engineered scaffold-based approaches.
Topics & Concepts
In vitroDrugHuman liverAnimal testingComputational biologyPharmacologyChemistryMedicineBiologyBiochemistryEcology3D Printing in Biomedical ResearchLiver physiology and pathologyBiomedical and Engineering Education